Early Career Investigators

Early Career Investigators

Rebecca C. Arend, MD

Assistant Professor, Gynecologic Oncology, UAB Comprehensive Cancer Center

Education: MD, Albert Einstein, New York, NY
OBGYN residency: Columbia Presbyterian, New York, NY
Gynecologic oncology fellowship: University of Alabama, Birmingham, AL

More information: https://providerdirectory.uabmedicine.org/provider/Rebecca++Arend/573564

Research Description

The overarching goals of my research are to understand tumor immune response to alterations in specific molecular pathways both in the tumor and in the tumor microenvironment. My basic and clinical research interests are focused on development of novel combination therapeutic approaches using targeted therapy, immunotherapy, and chemotherapy for treatment of patients with ovarian cancer. Specifically, I’m focusing on overcoming immune evasion by targeting the WNT pathway and ways to prime the immune systemic to change a “cold” tumor into a “hot” tumor so that they are more responsive to immunotherapy. Using syngeneic ovarian cancer mouse models, I am exploring sequencing and timing of therapy and investigating the specific effects on the microenvironment and specific subsets of immune cells. In addition, I am using human samples and genomics to better understand the relationship between Tumor Infiltrating Lymphocytes (TILs) to T regulatory cell ratios and gene expression in Homologous Recombination Deficiency and other conical cancer pathways.

Katherine Chiappinelli, PhD

Assistant Professor of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine 

Education: MD, PhD, Washington University in St. Louis School of Medicine; Postdoctoral fellowship, Johns Hopkins University

More information: https://smhs.gwu.edu/chiappinelli-lab/  

 

Research Description

My research focuses on how epigenetic therapies can be used against cancers, specifically in the context of arming the host immune system to fight cancer cells. We study the epigenetic changes in cancer and how epigenetic drugs can reverse these, specifically focusing on noncoding regions of the genome and the tumor cell immune response.

Salvatore Condello, PhD

Assistant Professor, Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN

Education: Ph.D., Cellular and Molecular Biology, University of Messina, Italy
Postdoc: Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN

More information: https://medicine.iu.edu/departments/obgyn/faculty/6232/condello-salvatore/

Research Description

My ongoing research aims at understanding the intersection between tissue transglutaminase, a multifunctional protein highly expressed in ovarian tumors, and the oncogenic Wnt/beta-catenin pathway in promoting the cancer stem cell phenotype, which has been associated with the clinically relevant problem of platinum resistance in ovarian cancer. My research program interrogates several ovarian cancer cell lines, primary cells, cancer stem-like cells, and animal models to address the importance of various signaling pathways and metabolic pattern alterations in this inherently heterogeneous disease with the ultimate goal to find new functional target genes and test novel therapeutics.

Juan R. Cubillos-Ruiz, PhD

Assistant Professor of Immunology in Obstetrics & Gynecology
Member, Sandra and Edward Meyer Cancer Center
Weill Cornell Medical College

Education:  Ph.D.: Tumor Immunology, Geisel School of Medicine at Dartmouth.
Post-doc: Harvard School of Public Health and Weill Cornell Medical College.

More information: http://vivo.med.cornell.edu/display/cwid-jur2016

Research description:

My research integrates immunology, cancer biology, genetics and nanotechnology to understand and disable the mechanisms that ovarian cancers use to paralyze and manipulate the protective function of immune cells. We currently focus on characterizing the role of abnormal stress responses in tumor-infiltrating immune cells, and we seek to exploit this knowledge for devising the next generation of targeted immunotherapies for ovarian cancer.

Sophia HL George, PhD

Assistant Professor, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami

Education: PhD, Molecular Genetics, University of Toronto, Ontario, Canada
Postdoc: Princess Margaret Cancer Center, Ontario, Canada and Duke University, Durham, NC

More information: https://umiamihealth.org/sylvester-comprehensive-cancer-center/research/faculty/sophia-george-phd

Research Description

The George lab studies Hereditary Breast and Ovarian Cancer syndrome, with the goal of understanding the effects of inherited genetic mutations on the fallopian tube epithelia and their involvement in the development of high-grade serous ovarian cancer. We hope to characterize the functional interplay between DNA damage response genes and antioxidant systems in early events in the fallopian tube epithelia as it is important to both prevention and chemotherapy resistance. Understanding the mechanisms that preneoplastic fallopian tube epithelia and ovarian cancer cells employ to circumvent oxidative stress and drive tumorigenesis will improve our ability to prevent and supplement treatment modalities.

David P├ępin, PhD

Assistant Professor, department Surgery, Massachusetts General Hospital, Harvard Medical School, Pediatric Surgical Research Laboratories.

Education: Post-doctoral fellowship: Massachusetts General Hospital, Harvard Medical School, Boston.

Doctorate: University of Ottawa, Canada.

More information: https://www.dfhcc.harvard.edu/insider/member-detail/member/david-pepin-phd/

Research Description

My laboratory studies the role of Mullerian Inhibiting Substance in female reproductive development and its application in the treatment of ovarian cancer. We are pursuing translational aspects of those discoveries such as single-cell transcriptomics and gene editing screens to identify synthetic lethality in chemoresistant ovarian cancer, and rapid target validation using viral and nanoparticle-based gene therapies in patient-derived xenografts.

Jogender Tushir-Singh, PhD

Assistant Professor of Biochemistry and Molecular Genetics, Member, Emily Couric Cancer Center, University of Virginia School of Medicine, Charlottesville VA

Education: Ph.D.  Cell and Molecular Biology, University Notre Dame, Notre Dame IN
Post Doctoral Studies: University of Massachusetts Medical School, Worcester MA

More information: https://med.virginia.edu/faculty/faculty-listing/js2yr/

Research Description

I am a rare early stage academic investigator who knows what it takes to translate research into the clinic due to both basic and industrial training. The overarching goals of my research are to investigate molecular mechanism of ovarian cancer and rationally apply antibody engineering based strategies for therapeutic targeting. We are particularly interested in dual-specificity antibodies, antibody conjugates and chimeric receptors. Current projects in my laboratory are focused on Bispecific Anchored Cytotoxic Activator strategy and CAR-NK cells against ovarian cancer overexpressed receptors. We currently focus on characterizing, comparing and combining both immune-dependent (Cancer Immunotherapy) and immune-independent strategies for effective ovarian cancer targeting. Additional projects are planned towards combinatorial ways to overcome clinical resistance to ovarian cancer therapies.

Rachel I. Vogel, PhD

Assistant Professor, Department of Obstetrics, Gynecology, and Women's Health, Medical School
University of Minnesota

Education: M.S.: Biostatistics and Ph.D.,  Epidemiology. University of Minnesota School of Public Health

More information: https://med.umn.edu/bio/obgyn-faculty/rachel-isaksson%20vogel

Research Description

My research focuses on cancer survivors with the end goal of maximizing survivors' quality of life and outcomes.  As the number of cancer survivors increases, the long-term effects of the disease and treatment have become a substantial public health concern. The goal of this funded research is to determine whether CMV (cytomegalovirus) reactivation in the presence of high inflammation contributes to patient-reported fatigue and negatively affects cancer prognosis among women with ovarian cancer. 

Oladapo Yeku, MD, PhD

Instructor, Medicine, Harvard Medical School, Clinical Assistant Attending, Medicine, Massachusetts General Hospital

Education: MD, PhD, Stony Brook University School of Medicine

Medical Oncology Fellowship, Memorial Sloan Kettering Cancer Center

More information: https://www.massgeneral.org/cancer-center/doctors/20425/Oladapo-Yeku

Research Description

I am characterizing the suppressive tumor microenvironment and evaluating strategies to improve the efficacy of novel immunotherapeutic approaches for the management of gynecologic malignancies. This includes immune checkpoint inhibitors, antibody-drug conjugates, bispecific T-cell engager therapy, and adoptive cellular therapy, including CAR-T cells.

Dmitriy Zamarin, MD, PhD

Assistant Attending Physician, Gynecologic Medical Oncology and Immunotherapeutics, Memorial Sloan Kettering Cancer Center

Education: MD/PhD, Mount Sinai School of Medicine, New York, NY
Internal medicine residency: Mount Sinai Hospital, New York, NY
Medical oncology fellowship: Memorial Sloan Kettering Cancer Center, New York, NY

More information: https://www.mskcc.org/research/ski/labs/members/dmitriy-zamarin
https://www.parkerici.org/person/dmitriy-zamarin-md-phd/

Research Description

My basic and clinical research interests are focused on development of novel immunotherapies using locoregional and systemic approaches for treatment of patients with ovarian cancer. Specifically, I’m focusing on oncolytic viruses, a novel class of immune therapeutics that can activate anti-tumor immunity through multiple mechanisms.  By studying the interaction of genetically engineered oncolytic viruses with the tumor microenvironment in mouse tumor models, the goals of my research are to identify pathways of immune response and adaptive immune resistance and to develop novel therapeutic combinations targeting these pathways directly within the tumor and systemically.